Azelastine Nasal Spray Price in Pakistan in This Randomized Placebo-controlled Clinical Trial That Included 450 Participants, the Incidence of Laboratory-confirmed Sars-cov-2 Infections Was Significantly Lower With Application of Azelastine Nasal Spray Compared With Placebo Treatment.
Importance Limited Pharmaceutical Options Exist for Preexposure Prophylaxis of Covid-19 Beyond Vaccination. Azelastine, an Antihistamine Nasal Spray Used for Decades to Treat Allergic Rhinitis, Has in Vitro Antiviral Activity Against Respiratory Viruses, Including Sars-cov-2.
Objective to Determine the Efficacy and Safety of Azelastine Nasal Spray for Prevention of Sars-cov-2 Infections in Healthy Adults.
Conclusions and Relevance in This Single-center Trial, Azelastine Nasal Spray Was Associated With Reduced Risk of Sars-cov-2 Respiratory Infections. These Findings Support the Potential of Azelastine as a Safe Prophylactic Approach Warranting Confirmation in Larger, Multicentric Trials.
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